Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Background This cross-sectional study aimed to identify latent sensitization profiles of asthma patients in mainland China, unveiling the association between regional differences and patterns. Methods 1056 participants from 10 medical centers divided into eastern western cohorts were clustered four individual patterns, respectively, by using an unsupervised statistical modeling method, class analysis (LCA), based on levels 12 aeroallergens specific IgE reactivities. Moreover, clinical characteristics environmental exposures compared different Results Four distinct patterns two defined as follows, respectively. Eastern cohort: Class 1: “High weed pollen house dust mites (HDMs) sensitization” (8.87%), 2: “HDMs dominated (38.38%), 3: HDMs animal dander (6.95%), 4: “Low/no aeroallergen (45.80%). Western (26.14%), multi-pollen (15.02%), “HDMs-dominated (10.33%), (48.51%). Of note, significant difference age, control test score (ACT) comorbidities observed within or Exposure factors pointed out. Conclusions Asthmatic with identified through LCA disclosing relationship multiple geographical differences, providing novel insights potential strategies for atopic disease monitoring, management prevention practice.